Top 15 VC Firms Dominating Blockchain, AI, and Healthtech Investments
The tech-health intersection is heating up, with innovations in blockchain, artificial intelligence, and healthtech reshaping the future. For investors and healthcare professionals, knowing the leading VC firms in these areas can be key to unlocking transformative funding connections. Here are the top 15 venture capital firms at the forefront of these industries:
1. Andreessen Horowitz (a16z)
Fund Size: $35 billion
Number of Investments: 1,100+
Description: Andreessen Horowitz has long been a powerhouse in blockchain, AI, and healthtech. With dedicated funds targeting these sectors, a16z has supported standout companies like Coinbase, BioAge, and OpenAI. Their deep expertise and network make them a go-to for cutting-edge investments.
Website: https://www.a16z.com
2. Sequoia Capital
Fund Size: $80 billion
Number of Investments: 1,200+
Description: Sequoia is a name synonymous with innovation, heavily backing companies that are disrupting traditional sectors. Their investments in healthtech startups like Medable and AI unicorns like UiPath prove their commitment to shaping the future of health and technology.
Website: https://www.sequoiacap.com
3. GV (formerly Google Ventures)
Fund Size: $8 billion
Number of Investments: 500+
Description: GV focuses on investing in high-potential startups across healthtech and AI, with a growing interest in blockchain. Their portfolio includes Verve Therapeutics, a leader in genetic medicines, as well as deep investments in AI with companies like Flatiron Health.
Website: https://www.gv.com
4. Lux Capital
Fund Size: $4 billion
Number of Investments: 200+
Description: Lux Capital is known for its bold bets in healthtech, AI, and frontier tech. Their portfolio features pioneers like Auris Health (robotics in surgery) and Recursion Pharmaceuticals (AI-driven drug discovery). Lux Capital is deeply committed to pushing technological and scientific boundaries.
Website: https://www.luxcapital.com
5. DCVC (Data Collective)
Fund Size: $2 billion
Number of Investments: 300+
Description: Focused on deep tech, DCVC has been investing in groundbreaking blockchain, AI, and healthtech companies. Their portfolio includes Zymergen (AI-driven bioengineering) and Dapper Labs (blockchain entertainment), signaling their ability to support revolutionary tech ventures.
Website: https://www.dcvc.com
6. Bessemer Venture Partners
Fund Size: $19 billion
Number of Investments: 900+
Description: Bessemer has played an integral role in the digital health and AI landscape, investing in companies like Bright Health and PagerDuty. They target scalable, high-impact healthtech innovations that address current challenges in healthcare.
Website: https://www.bvp.com
7. Insight Partners
Fund Size: $90 billion
Number of Investments: 600+
Description: Insight Partners focuses on growth-stage investments, especially in AI and healthtech. With investments in companies like 1stDibs and Tractable, Insight is helping scale innovative technology companies and bringing AI solutions to broader audiences.
Website: https://www.insightpartners.com
8. Pantera Capital
Fund Size: $1 billion
Number of Investments: 100+
Description: Pantera Capital is known for its focus on blockchain technology and cryptocurrency. With a wide array of investments across DeFi and blockchain infrastructure, Pantera is an ideal partner for startups working at the intersection of healthcare and blockchain.
Website: https://www.panteracapital.com
9. Khosla Ventures
Fund Size: $15 billion
Number of Investments: 700+
Description: Khosla Ventures is a heavy hitter in healthtech and AI, investing in transformative companies like Oscar Health and Atomwise. Vinod Khosla’s belief in the power of technology to drive medical and societal change has led the firm to target startups addressing major healthcare challenges.
Website: https://www.khoslaventures.com
10. Founders Fund
Fund Size: $11 billion
Number of Investments: 300+
Description: Founders Fund, co-founded by Peter Thiel, has a diverse portfolio encompassing healthtech, AI, and blockchain. Investments include Stemcentrx (oncology) and Layer1 (blockchain infrastructure), highlighting their commitment to breakthrough technologies.
Website: https://www.foundersfund.com
11. SoftBank Vision Fund
Fund Size: $100 billion
Number of Investments: 1,000+
Description: With its enormous investment capacity, SoftBank Vision Fund has supported leading AI and healthtech companies, such as Ro and ClimaCell. Their appetite for ambitious, global projects makes them a key player in the intersection of tech and healthcare.
Website: https://www.softbank.jp/en/vf/
12. Lightspeed Venture Partners
Fund Size: $18 billion
Number of Investments: 400+
Description: Lightspeed has emerged as a strong supporter of AI and healthtech initiatives. Their investments in startups like Tempus (health data analytics) and SnapLogic (AI integration) show their dedication to fostering growth in data-driven health solutions.
Website: https://www.lsvp.com
13. Blockchain Capital
Fund Size: $500 million
Number of Investments: 100+
Description: Blockchain Capital focuses exclusively on blockchain and related technologies, making them an essential partner for healthtech startups incorporating blockchain solutions. Their diverse portfolio includes Ripple and Anchorage, both of which provide core blockchain infrastructure.
Website: https://www.blockchain.capital
14. 8VC
Fund Size: $3.5 billion
Number of Investments: 150+
Description: 8VC invests in companies solving fundamental societal issues through technology. Their investments span healthtech and blockchain, with a particular emphasis on enterprise solutions that leverage AI, like Oscar Health and Notable Labs.
Website: https://www.8vc.com
15. SOSV
Fund Size: $1 billion
Number of Investments: 1,000+
Description: SOSV’s focus on accelerator programs like IndieBio and HAX makes them one of the most hands-on VCs in the healthtech and AI space. By providing both funding and mentorship, they help guide early-stage startups toward sustainable growth.
Website: https://sosv.com
Conclusion
The intersection of blockchain, AI, and healthtech is creating immense opportunities for disruptive innovation. These 15 venture capital firms are not only leading investments in these rapidly evolving sectors but are also instrumental in driving the next wave of tech-health transformation. For startups and healthcare professionals alike, connecting with these VCs could provide the needed spark to take revolutionary ideas to the next level.
If you’re a startup or healthcare professional looking to partner with one of these VCs, reach out and seize the opportunity to be part of the tech-health evolution.
